Thromboxane A2-mediated L-type Calcium Channel Activation in the Vasculature
نویسندگان
چکیده
منابع مشابه
Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2.
The role of T-type Ca2+ channels for cardiovascular physiology, in particular blood pressure regulation, is controversial. Selective blockade of T-type Ca2+ channels in resistance arteries has been proposed to explain the effect of the antihypertensive drug mibefradil. In the present study, we used a third generation, time- and tissue-specific conditional knockout model of the L-type Ca2+ chann...
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ژورنال
عنوان ژورنال: Heart, Lung and Circulation
سال: 2012
ISSN: 1443-9506
DOI: 10.1016/j.hlc.2012.05.068